Synthesis and Evaluation of Cytotoxic Activity of 3-((1H-Benzo[d]imidazol-2-yl)methyl)-2-phenylquinazolin-4(3H)-one Derivatives on MCF-7 Cell Line

biological activity and efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one/thione derivatives

the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde,...

Synthesis and Cytotoxic Evaluation of Novel 3-Substituted Derivatives of 2-Indolinone

     The assessment of the degree or rate of cellular proliferation and cell viability is critical for the assessment of the effects of drugs on both normal and malignant cell populations. In the present study, a few novel 3-substituted derivatives of 2-indolinones were synthesized by condensation of substituted oxindole or isatin derivatives with appropriate aldehydes or primary aromatic amine...

Synthesis and Cytotoxic Evaluation of Novel 3-Substituted Derivatives of 2-Indolinone

     The assessment of the degree or rate of cellular proliferation and cell viability is critical for the assessment of the effects of drugs on both normal and malignant cell populations. In the present study, a few novel 3-substituted derivatives of 2-indolinones were synthesized by condensation of substituted oxindole or isatin derivatives with appropriate aldehydes or primary aromatic amine...

genotoxic effects of 2-methoxy and 2-methyl benzofuran phenylmethyl imidazole on mcf-7 cell line

Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line

Objectives: 7-prenyloxycoumarins are a group of secondary metabolites that are found mainly in plants belonging to the Rutaceae and Umbelliferae families. This study was designed to evaluate and compare the cytotoxic and apoptotic activity of 7-prenyloxycoumarin compounds and herniarin on MCF-7, a breast carcinoma cell line. Materials and Methods: Cells were cultured in RPMI medium and incubate...